Synthesis of 1,5-Disubstituted Tetrazoles in Aqueous Micelles at Room Temperature by Mohammed Abdessalam Madjid Ait Sidhoum Fatima-Zohra Zradni & Hocine Ilikti

Author:Mohammed Abdessalam, Madjid Ait Sidhoum, Fatima-Zohra Zradni & Hocine Ilikti
Format: pdf
Tags: The ongoing study is a Ugi-azide four-component reaction for the synthesis of 1,5-disubstituted tetrazole(1,5-DST), which involves an aldehyde, different amines, isocyanides, and as azide’s source the Trimethylsilylazide (TMSN3), in water as solvent using as catalyst the tetradecyltrimethylammonium bromide (TTAB) with a load of (10% mole), which provides a hydrophobic micellar reaction site. This approach is a step toward a green chemistry reaction of 1,5 disubstituted tetrazole. A serie of 1, 5- disubstituted tetrazole was synthesized by engaging a large substrate scope, leading to yields between 43% and 56%, which are compared afterwards with those obtained with methanol as solvent. The results were confirmed by HRMS, IR, and 1D NMR experiments., tetrazole; Ugi-azide multicomponent reaction instead of Ugiazide reaction; Ugi-azide multicomponent reaction; micellar catalysis; green chemistry


Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.